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Role of therapeutic plasma exchange in snake bite associated thrombotic microangiopathy—A case report with review of literature
Author(s) -
Mohan Ganesh,
Guduri Pruthvi Raj,
Shastry Shamee
Publication year - 2019
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.21691
Subject(s) - thrombotic microangiopathy , therapeutic plasma exchange , medicine , envenomation , acute kidney injury , hemodialysis , schistocyte , microangiopathy , therapeutic approach , plasmapheresis , intensive care medicine , dermatology , surgery , thrombotic thrombocytopenic purpura , venom , immunology , diabetes mellitus , endocrinology , platelet , ecology , disease , antibody , biology
Abstract Post snake bite renal failure due to thrombotic microangiopathy (TMA) is often overlooked and not considered as a separate entity while managing the patient. This case report highlights the efficacy of Therapeutic Plasma Exchange in managing the post envenomation TMA. Anti‐snake venom was administered following severe hematotoxic envenomation, but later on developed acute kidney injury and hence hemodialysis was done for 2 days without much improvement. On third day of bite, diagnosis of TMA was made from microangiopathic hemolytic picture in peripheral blood smear, thrombocytopenia and renal failure. Therapeutic plasma exchange with human albumin solution was started on a daily basis and after 3 cycles, patient's condition improved as shown by the laboratory parameters. Though this entity is not well defined, the supporting evidence is found in few reports of published literature. Hence, we propose plasma exchange as an adjunctive therapeutic option in post snake TMA.