G‐CSF mobilized peripheral blood stem cell collection for allogeneic transplantation in healthy donors: Analysis of factors affecting yield

Mobilized PBSC are the main source for allogeneic HSCT. We aimed to evaluate factors that affect CD34+ cell yield including the donor's age, gender, BSA, processed blood volume and the method of G‐CSF dose calculation. Data from 170 healthy donors were analyzed. The concentration of CD34+ cells in the peripheral blood (PB) and the processed volume of blood were significantly correlated to CD34+ cells yield ( P  < .00005 and P  < .001, respectively). The G‐CSF dose per m 2 was significantly correlated to the concentration of CD34+ cells in the PB ( P  = .0003) and in the product ( P  = .01). Smaller BSA and less processed volume were found among female donors, who were given lesser G‐CSF dose per m 2 , and showed lower yield compared to men. However, multivariate analysis of the yield showed that only the concentration of CD34+ cells in the PB and the processed volume remained independent significant.