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Therapeutic plasma exchange as treatment for propofol infusion syndrome
Author(s) -
Levin Phillip D.,
Levin Valentin,
Weissman Charles,
Sprung Charles L.,
Rund Deborah
Publication year - 2015
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.21376
Subject(s) - medicine , propofol , status epilepticus , anesthesia , lactic acidosis , therapeutic plasma exchange , phenytoin , complication , hemodynamics , rhabdomyolysis , sedation , acidosis , surgery , epilepsy , psychiatry
Propofol infusion syndrome (PRIS), a rare complication of propofol sedation, is associated with high mortality. There is no specific therapy. A 16‐year‐old with head injury and status epilepticus is described. Three days after seizure resolution, whilst receiving propofol, he developed severe lactic acidosis, rhabdomyolysis, and hemodynamic instability. Suspected PRIS was treated with a single session of therapeutic plasma exchange (TPE). This was associated with immediate improvement in hemodynamic status, resolution of lactic acidosis within 24 h, normalization of CPK over 10 days, and a subsequent full recovery. TPE is suggested as a novel therapy for PRIS. J. Clin. Apheresis 30:311–313, 2015. © 2015 Wiley Periodicals, Inc.