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Carfilzomib associated thrombotic microangiopathy initially treated with therapeutic plasma exchange
Author(s) -
Sullivan Matthew R.,
Danilov Alexey V.,
Lansigan Frederick,
Dunbar Nancy M.
Publication year - 2015
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.21371
Subject(s) - medicine , thrombotic microangiopathy , therapeutic plasma exchange , carfilzomib , pharmacology , intensive care medicine , multiple myeloma , proteasome inhibitor , disease
Drug associated thrombotic microangiopathy (TMA) is a rare event causing thrombocytopenia, microangiopathic anemia, renal failure, and neurologic abnormalities. Here, we present a case of TMA that occurred during the first cycle of treatment with carfilzomib for relapsed multiple myeloma. J. Clin. Apheresis, 2014. © 2014 Wiley Periodicals, Inc.