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The use of plasma exchange in H ashimoto's encephalopathy: A case report and review of the literature
Author(s) -
Cook Melissa K.,
Malkin Mark,
Karafin Matthew S.
Publication year - 2015
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.21353
Subject(s) - medicine , therapeutic plasma exchange , apheresis , context (archaeology) , encephalopathy , myoclonus , psychosis , plasmapheresis , antibody , intensive care medicine , pediatrics , immunology , anesthesia , psychiatry , platelet , paleontology , biology
Hashimoto's Encephalopathy (HE) is a very rare condition characterized by psychosis, seizures, cognitive fluctuations, and myoclonus. In a few published cases, plasma exchange has been used due to the theoretical removal of antithyroid peroxidase antibodies (anti‐TPO), one of the postulated causes of the condition. We report a case of HE treated by plasma exchange where no clinical or neurophysiologic improvement was observed despite documented reduction of the anti‐TPO antibody to levels below the limits of laboratory detection. We discuss these findings in the context of the known literature for this disease process. J. Clin. Apheresis 30:188–192, 2015. © 2014 Wiley Periodicals, Inc.