Premium
A retrospective study of autologous stem cell mobilization to guide an immediate salvage protocol using plerixafor for patients who mobilize stem cells poorly
Author(s) -
Hay Annette Elizabeth,
Lawrie Alastair,
Robinson Nicolas,
Dong Bin,
Culligan Dominic J.
Publication year - 2013
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.21274
Subject(s) - plerixafor , medicine , apheresis , mobilization , stem cell , cd34 , logistic regression , salvage therapy , surgery , oncology , chemotherapy , cxcr4 , platelet , genetics , chemokine , receptor , archaeology , biology , history
The addition of plerixafor to G‐CSF decreases the risk of failed stem cell collection, but at considerable extra cost. Using a logistic regression model based on 354 autologous mobilizations, we have identified a local minimum peripheral blood CD34 count at which the probability of a successful collection is 50%. This seems an appropriate CD34 count at which to add immediate salvage plerixafor. J. Clin. Apheresis 28:378–380, 2013. © 2013 Wiley Periodicals, Inc.