A retrospective study of autologous stem cell mobilization to guide an immediate salvage protocol using plerixafor for patients who mobilize stem cells poorly | Zendy

Hay Annette Elizabeth | Zendy; Lawrie Alastair | Zendy; Robinson Nicolas | Zendy; Dong Bin | Zendy; Culligan Dominic J. | Zendy

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A retrospective study of autologous stem cell mobilization to guide an immediate salvage protocol using plerixafor for patients who mobilize stem cells poorly

Author(s) -

Hay Annette Elizabeth,

Lawrie Alastair,

Robinson Nicolas,

Dong Bin,

Culligan Dominic J.

Publication year - 2013

Publication title -

journal of clinical apheresis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.697

H-Index - 46

eISSN - 1098-1101

pISSN - 0733-2459

DOI - 10.1002/jca.21274

Subject(s) - plerixafor , medicine , apheresis , mobilization , stem cell , cd34 , logistic regression , salvage therapy , surgery , oncology , chemotherapy , cxcr4 , platelet , genetics , chemokine , receptor , archaeology , biology , history

The addition of plerixafor to G‐CSF decreases the risk of failed stem cell collection, but at considerable extra cost. Using a logistic regression model based on 354 autologous mobilizations, we have identified a local minimum peripheral blood CD34 count at which the probability of a successful collection is 50%. This seems an appropriate CD34 count at which to add immediate salvage plerixafor. J. Clin. Apheresis 28:378–380, 2013. © 2013 Wiley Periodicals, Inc.

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