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Thrombotic thrombocytopenic purpura precipitated by thyrotoxicosis
Author(s) -
Chhabra Saurabh,
Tenorio Grace
Publication year - 2012
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.21210
Subject(s) - medicine , thrombotic thrombocytopenic purpura , therapeutic plasma exchange , apheresis , microangiopathic hemolytic anemia , hemolytic anemia , autoimmune hemolytic anemia , graves' disease , plasmapheresis , thrombocytopenic purpura , immunology , autoimmune disease , anemia , immune system , disease , dermatology , gastroenterology , platelet , antibody
Thrombotic thrombocytopenic purpura (TTP) may be seen in association with autoimmune disorders such as immune hemolytic anemia and systemic lupus erythematosus, but rarely has it been associated with Graves' disease. We report one such case of a woman with new‐onset thyrotoxicosis caused by Graves' disease, who abruptly developed TTP, confirmed by low serum ADAMTS‐13 value. She had a dramatic response to plasma exchange, with remission of TTP. Definitive treatment with radioactive iodine resulted in euthyroidism and has prevented recurrence of TTP. J. Clin. Apheresis 27:265–266, 2012. © 2012 Wiley Periodicals, Inc.