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Mucosal healing of esophageal involvement of Crohn's disease with granulocyte/monocyte adsorption
Author(s) -
Moribata Kosaku,
Kato Jun,
Iimura Sae,
Yoshida Satoshi,
Shingaki Naoki,
Ueda Kazuki,
Deguchi Hisanobu,
Inoue Izumi,
Maekita Takao,
Iguchi Mikitaka,
Tamai Hideyuki,
Ichinose Masao
Publication year - 2011
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.20295
Subject(s) - medicine , odynophagia , gastroenterology , apheresis , exacerbation , esophageal ulcer , adverse effect , diarrhea , esophagus , surgery , platelet
We report a case of a 16‐year‐old male who suffered from Crohn's disease (CD) with esophageal involvement, showing remarkable improvement with granulocyte/monocyte adsorption (GMA). The patient had been diagnosed as ileocolic CD and was treated with 5‐aminosalicylate. He was admitted to our hospital with symptoms of fever, diarrhea, and odynophagia. Endoscopic examinations revealed that the exacerbation of ileocolic ulcers, and advent of ulcers in esophagus. Because of the patient's refusal to receive corticosteroids, immunomodulators, or biologics, he underwent GMA twice a week. After 10 sessions of GMA, he entered remission with significant decrease in clinical activity. In addition, endoscopic examinations showed remarkable improvement of ileocolic ulcers and disappearance of esophageal lesions. No adverse events were observed. GMA could be effective for manifestations of CD in gastrointestinal tract other than ileum or colon. J. Clin. Apheresis, 2011. © 2011 Wiley‐Liss, Inc.