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Early plasmapheresis followed by high‐dose γ‐globulin treatment saved a severely Rho‐incompatible pregnancy
Author(s) -
Isojima Sakiko,
Hisano Michi,
Suzuki Teruaki,
Sago Haruhiko,
Murashima Atsuko,
Yamaguchi Koushi
Publication year - 2011
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.20288
Subject(s) - medicine , plasmapheresis , pregnancy , fetus , apheresis , titer , obstetrics , antibody , immunology , platelet , genetics , biology
An alloimmunized pregnancy induces anemia in the fetus and can ultimately lead to fetal hydrops and intrauterine fetal death. A woman with a severe Rho‐incompatible pregnancy had experienced frequent pregnancies with fetomaternal transfusion without receiving RhIg and had high anti‐D antibody titers present from early pregnancy. We succeeded in long‐term inhibition of antibody production using plasmapheresis followed by high‐dose γ‐globulin treatment in early pregnancy. J. Clin. Apheresis, 2011. © 2011 Wiley‐Liss, Inc.