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Alteration of adipokines during peripheral blood stem cell mobilization induced by granulocyte colony‐stimulating factor
Author(s) -
Tanaka Yoshinori,
Yujiri Toshiaki,
Tanaka Mayumi,
Mitani Noriyuki,
Tanimura Atsuko,
Tanizawa Yukio
Publication year - 2009
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.20212
Subject(s) - medicine , granulocyte colony stimulating factor , adipokine , mobilization , granulocyte , immunology , peripheral blood , stem cell , microbiology and biotechnology , leptin , obesity , biology , chemotherapy , archaeology , history
Abstract Adipokines, soluble mediators produced by adipocytes, have been shown to play a role in various physiological and pathological conditions. We investigated the involvement of adipokines in granulocyte colony‐stimulating factor (G‐CSF)‐induced mobilization of hematopoietic stem cells in 21 healthy donors. We found that serum visfatin and resistin levels, but not leptin and adiponectin levels, were significantly elevated by G‐CSF treatment. G‐CSF treatment activated signaling proteins like extracellular signal‐regulated kinase and stimulated secretion of visfatin from 3T3‐L1 adipocytes. These findings suggest that some adipokines may play a role in G‐CSF‐induced mobilization of stem cells from the bone marrow into systemic circulation. J. Clin. Apheresis 2009. © 2009 Wiley‐Liss, Inc.