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Plasmapheresis and intravenous immune globulin for the treatment of D alloimmunization in pregnancy
Author(s) -
Novak Deborah J.,
Tyler Lisa N.,
Reddy Ramakrishna L.,
Barsoom Michael J.
Publication year - 2008
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.20180
Subject(s) - medicine , plasmapheresis , pregnancy , fetus , anemia , gestation , apheresis , obstetrics , immunology , antibody , platelet , genetics , biology
The alloimmunized pregnancy can result in fetal and newborn mortality due to fetal anemia. Control of fetal anemia has not been possible until recently, and management consists of following the degree of fetal anemia during gestation until intrauterine transfusion is feasible to support the fetus until delivery. Cordocentesis and intrauterine transfusion have potential complications that have been well documented. Control of fetal anemia via immune modulation utilizing plasmapheresis and intravenous immune globulin administration has been attempted alone and in combination with varying results. We present a case report of an Rh(D) alloimmunized pregnancy, in which successful management consisted of initial therapeutic plasmapheresis (TPE) followed by intravenous immunoglobulin (IVIG) administration until delivery at 37 weeks gestation without the need for intrauterine transfusion. J. Clin. Apheresis, 2008. © 2008 Wiley‐Liss, Inc.