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Plasma exchange as treatment for Lawsone (henna) intoxication
Author(s) -
Rund Deborah,
Schaap Tova,
Da'as Nael,
Yehuda Dina Ben,
Kalish Joseph
Publication year - 2007
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.20128
Subject(s) - lawsone , medicine , plasmapheresis , ingestion , surgery , toxicology , dermatology , immunology , pathology , biology , antibody
Abstract Lawsone (2‐hydroxy‐1,4‐naphthoquinone) is the active ingredient of Lawsonia alba, whose crushed leaves are known as henna, used as a hair and skin dye in many parts of the world. Accidental or deliberate ingestion of Lawsone has a high mortality rate (up to 31%) owing to rhabdomyolysis and renal failure. The authors report the first successful use of plasmapheresis as an adjunct to the treatment of these symptoms in a 69‐year‐old man who suffered severe symptoms of Lawsone poisoning due to inadvertent ingestion. Although most cases reported in the literature have been treated using supportive techniques, including hemodialysis, the high mortality despite these measures suggests that prompt plasma exchange may be a lifesaving technique for this syndrome. J. Clin. Apheresis., 2007. © 2007 Wiley‐Liss, Inc.