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Acute hemolytic transfusion reaction in a pediatric patient following transfusion of apheresis platelets
Author(s) -
Sapatnekar Suneeti,
Sharma Girish,
Downes Katharine A.,
Wiersma Susan,
McGrath Claire,
Yomtovían Roslyn
Publication year - 2005
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.20072
Subject(s) - medicine , apheresis , hemolysis , platelet , abo blood group system , platelet transfusion , complication , mean platelet volume , blood product , plasma volume , surgery , intensive care medicine , immunology
The practice of transfusing ABO‐incompatible platelets, driven primarily by concerns about inventory management, has been considered generally safe because the accompanying plasma is usually diluted in the recipient's total blood volume. However, if the platelet product contains a large volume of plasma or a high concentration of incompatible isoagglutinin, there may be hemolysis of the recipient's red cells. Patients with a small blood volume, such as babies and children, are considered to be at particular risk for such a complication. We describe the case of a baby who suffered massive hemolysis of her group A red cells after transfusion of group O Apheresis Platelets containing a high‐titered anti‐A isoagglutinin. We also offer a review of the literature on this subject and recommendations to avoid acute hemolytic reactions as a result of platelet transfusion. J. Clin. Apheresis 2005. © 2005 Wiley‐Liss, Inc.