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Fulminant hepatic failure associated with propylthiouracil: A case report with treatment emphasis on the use of plasmapheresis
Author(s) -
Aydemir Selim,
Ustundag Yucel,
Bayraktaroglu Taner,
Tekin Ishak Ozel,
Peksoy Irfan,
Unal Aysun Uroglu
Publication year - 2005
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.20063
Subject(s) - propylthiouracil , medicine , plasmapheresis , fulminant hepatic failure , fulminant , intensive care medicine , surgery , immunology , liver transplantation , transplantation , thyroid , antibody
Propylthiouracil is a commonly used medication for hyperthyroidism. Though propylthiouracil‐induced hepatotoxicity is a rarely encountered problem, death due to fulminant hepatic failure may occur. In the English literature, only 34 cases have been described with severe hepatotoxicity secondary to this drug. Here we report a case of fulminant hepatic failure due to propylthiouracil and review the issues of treatment and management with special emphasis on the use of plasmapheresis in such situations. J Clin Apheresis 2005. © 2005 Wiley‐Liss, Inc.