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Consanguineous hemolytic uremic syndrome secondary to Escherichia coli O157:H7 infection treated with aggressive therapeutic plasma exchange
Author(s) -
Downes Katharine A.,
Allen Kathleen,
Sarode Ravindra,
Yomtovian Roslyn
Publication year - 2001
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.1029
Subject(s) - medicine , fresh frozen plasma , platelet , wife , escherichia coli , immunology , pediatrics , gastroenterology , biology , political science , law , gene , biochemistry
We describe the successful management of an elderly husband and wife with Escherichia coli O157:H7 associated hemolytic uremic syndrome (HUS) treated with aggressive therapeutic plasma exchange (TPE) with replacement with fresh frozen plasma. Following twelve TPEs (three 1.5 volume; nine 1 volume), the husband's platelet count increased from 45 × 10 9 /L to 183 × 10 9 /L. Following ten 1.5 volume TPEs, the wife's platelet count increased from 30 × 10 9 /L to 193 × 10 9 /L. This is the first known occurrence of E. coli O157:H7 associated HUS in an elderly husband and wife successfully treated with aggressive TPE. We conclude that early, aggressive TPE should be considered and may be life‐saving for E coli O157:H7 associated HUS in the elderly. J. Clin. Aperesis 16:155–156, 2001 © 2001 Wiley‐Liss, Inc.