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Apheresis treatment of recurrent focal segmental glomerulosclerosis after kidney transplantation: Re‐analysis of published case‐reports and case‐series
Author(s) -
Davenport Robertson D.
Publication year - 2001
Publication title -
journal of clinical apheresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.697
H-Index - 46
eISSN - 1098-1101
pISSN - 0733-2459
DOI - 10.1002/jca.10007
Subject(s) - medicine , plasmapheresis , apheresis , surgery , regimen , transplantation , kidney transplantation , single center , focal segmental glomerulosclerosis , glomerulosclerosis , urology , kidney , proteinuria , platelet , antibody , immunology
A systematic re‐analysis of published cases was performed to better define the role of plasmapheresis in the treatment recurrent focal segmental glomerulosclerosis after renal transplantation. Forty‐four cases were identified, of which 32 responded to apheresis. The median number of treatments to response was 9. There was no difference between responders and nonresponders in the total number of treatments performed. The presence of sclerosis on biopsy predicted treatment failure. Relapse after first successful treatment was reported in 10 cases. The median number of treatments received was less and the time from diagnosis to first treatment was greater for patients who relapsed than for patients in whom relapse was not reported, but the differences were not statistically significant. On the basis of this analysis, we recommend early treatment after diagnosis with a regimen of three daily plasmapheresis treatments followed by 6 treatments on an every other day basis. J. Clin. Apheresis 16:175–178, 2001. © 2001 Wiley‐Liss, Inc.