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Evaluation of 17 genetic variants in association with leukemia in the north Indian population using MassARRAY Sequenom
Author(s) -
Bhat Amrita,
Bhat Gh. Rasool,
Verma Sonali,
Sharma Bhanu,
Bakshi Divya,
Abrol Deepak,
Singh Supinder,
Qadri Raies Ahmed,
Shah Ruchi,
Kumar Rakesh
Publication year - 2021
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22792
Subject(s) - single nucleotide polymorphism , leukemia , allele , biology , genetic association , genetics , population , medicine , oncology , gene , genotype , environmental health
Leukemia is a heterogeneous disorder, characterized by elevated proliferation of white blood cells. In this study, we explored the association of 17 genetic variants with leukemia patients in the Jammu and Kashmir region of north India. The variants were genotyped by using a high‐throughput Agena MassARRAY platform in 758 individuals (166 cases and 592 controls). Of the 17 single‐nucleotide polymorphisms (SNPs) studied, five SNPs were showing significant association with the high risk of leukemia in the north Indian population, which includes rs10069690 of telomere reverse transcriptase ( TERT ) with OR = 0.34 (95% CI, 0.20–0.58; p = .0008), rs2972392 ( PSCA ) with OR 1.86 (95% CI, 1.04–3.81; p = .035), rs4986764 ( BRIP1 ) with OR 1.34 (95% CI, 1.00–1.80; p = .04), rs6990097 ( TNKS ) with OR 1.81 (95% CI, 1.2–2.6; p = .001) and rs12190287 ( TCF21 ) with OR 2.87 (95% CI, 1.72–4.7; p = .0001) by allelic association using Plink and analyzed by SPSS. This is the first study to explore these variants with leukemia in the studied population.