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Natural compounds against cytotoxic drug‐induced cardiotoxicity: A review on the involvement of PI3K/Akt signaling pathway
Author(s) -
Yarmohammadi Fatemeh,
Hayes A. Wallace,
Karimi Gholamreza
Publication year - 2021
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22683
Subject(s) - cardiotoxicity , protein kinase b , pi3k/akt/mtor pathway , pharmacology , cytotoxic t cell , chemistry , autophagy , apigenin , apoptosis , medicine , biochemistry , antioxidant , flavonoid , toxicity , organic chemistry , in vitro
Cardiotoxicity is a critical concern in the use of several cytotoxic drugs. Induction of apoptosis, inflammation, and autophagy following dysregulation of the PI3K/Akt signaling pathway contributes to the cardiac damage induced by these drugs. Several natural compounds (NCs), including ferulic acid, gingerol, salvianolic acid B, paeonol, apigenin, calycosin, rutin, neferine, higenamine, vincristine, micheliolide, astragaloside IV, and astragalus polysaccharide, have been reported to suppress cytotoxic drug‐induced cardiac injury. This article reviews these NCs that have been reported to have a protective effect against cytotoxic drug‐induced cardiotoxicity through regulation of the PI3K/Akt signaling pathway.