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Arsenic(III) mixed derivatives having oximes and morpholinedithiocarbamate along with their cytotoxic, antimicrobial, and antioxidant studies
Author(s) -
Beniwal Savita,
Sangwan Reena,
Singh Yashpal,
Sharma Jyoti
Publication year - 2020
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22581
Subject(s) - chemistry , arsenic , nuclear chemistry , antioxidant , antimicrobial , ferric , antifungal , stoichiometry , infrared spectroscopy , stereochemistry , medicinal chemistry , inorganic chemistry , organic chemistry , medicine , dermatology
Consecutive substitution reactions of arsenic(III)chloride with sodium salts of various oximes and morpholinedithiocarbamate (morphdtc) were carried out in 1:2:1 stoichiometry to obtain six new arsenic(III) mixed derivatives of the type: [(R)(R 1 )C = NO] 2 Sb[S 2 CN(CH 2 CH 2 ) 2 O] [where R is –C 6 H 5 , R 1 = –CH 3 ( 1 ); R = –C 6 H 4 CH 3 , R 1 = –CH 3 ( 2 ); R = –C 6 H 4 Cl, R 1 = –CH 3 ( 3 ); R = –C 6 H 4 Br, R 1 = –CH 3 ( 4 ); R = –C 6 H 4 OH, R 1 = –H ( 5 ); R(R 1 )C = ( 6 )]. These derivatives are characterized by elemental and physicochemical analyses and the tentative distorted trigonalbipyramidal geometry around arsenic assigned using spectral data of infrared ( 1 H, 13 C) nuclear magnetic resonance and liquid chromatography‐mass. Powder X‐ray diffraction study revealed their nanoranged particle size to be approximately 40 nm and crystalline nature. These derivatives examined against microbes and results revealed that these derivatives expressed more antifungal potential than antibacterial. The antioxidant activity was carried out by ferric reducing ability of plasma assay, and the cytotoxic study was performed in 3T 3 fibroblast cell lines by tetrazolium‐based colorimetric assay.