Premium
Identification of markers of depression and neurotoxicity in pesticide exposed agriculture workers
Author(s) -
Kori Rajesh K.,
Mandrah Kapil,
Hasan Whidul,
Patel Devendra K.,
Roy Somendu K.,
Yadav Rajesh S.
Publication year - 2020
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22477
Subject(s) - neurochemical , homovanillic acid , urine , dopamine , pesticide , medicine , endocrinology , monoamine neurotransmitter , beck depression inventory , acetylcholinesterase , serotonin , chemistry , biology , psychiatry , biochemistry , enzyme , receptor , agronomy , anxiety
Earlier, we reported that chronic exposure to pesticides causes a reduction in the acetylcholinesterase activity and hematological and biochemical alterations in agriculture workers. In continuation with that, the present study aimed to investigate the pesticide‐induced neurochemical imbalance and its association with behavior alterations in agricultural workers. A significant increase in depressive symptoms, assessed by the Beck Depression Inventory‐II was observed in pesticide exposed workers as compared to the unexposed. A decrease in the level of dopamine in plasma and levels of dopamine, 3,4‐dihydroxyphenylacetic acid, homovanillic acids, norepinephrine, serotonin, and hydroxyindoleacetic acid in urine was also observed. An increase in the levels of MAO‐A and MAO‐B has also been observed in these individuals. The decreased levels of neurotransmitters in the blood and urine have been linked with increased levels of MAO and pesticide residues in plasma and urine. Furthermore, these changes were associated with a higher incidence of depression in agricultural workers.