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The investigation of therapeutic potential of oxytocin and liraglutide on vincristine‐induced neuropathy in rats
Author(s) -
Erdoğan Mümin A.,
Taşkıran Emin,
Yiğittürk Gürkan,
Erbaş Oytun,
Taşkıran Dilek
Publication year - 2020
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22415
Subject(s) - oxytocin , liraglutide , medicine , endocrinology , saline , lipid peroxidation , vincristine , anesthesia , oxidative stress , chemotherapy , diabetes mellitus , type 2 diabetes , cyclophosphamide
The aim of this study was to assess the therapeutic potential of oxytocin and liraglutide (LIR), a GLP‐1 analogue, in a rat model of vincristine‐induced neuropathy. Rats were injected with vincristine (VCR) at a dose of 4 mg/kg twice a week for 5 weeks. The VCR‐administered rats were divided into three groups and received saline, oxytocin, or liraglutide simultaneously with VCR. After the treatment period, electrophysiological, biochemical, histological, and immunohistochemical investigations were performed. Electromyography (EMG) recordings demonstrated significant alterations in the VCR + saline group ( p < .001). Also, motor performance was decreased in the VCR + saline group ( p < .05). Histologically, the axonal diameter was decreased in all groups. VCR + saline group showed significantly increased lipid peroxidation and decreased nerve growth factor (NGF) expression. However, the administration of oxytocin and liraglutide significantly prevented the EMG alterations, lipid peroxidation, and reduction in neuronal NGF expression. On the basis of these findings, oxytocin and liraglutide may be considered as potential agents for the prevention of VCR‐induced neuropathy.