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The modulatory effect of triclosan on the reversion of the activated phenotype of LX‐2 hepatic stellate cells
Author(s) -
Miranda Juliana F.,
Scarinci Letícia D.,
Ramos Letícia F.,
Silva Caio M.,
Gonçalves Letícia R.,
Morais Priscila F.,
Malaspina Osmar,
Moraes Karen C. M.
Publication year - 2020
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22413
Subject(s) - reversion , hepatic stellate cell , phenotype , biology , hepatic fibrosis , microbiology and biotechnology , fibrosis , chemistry , biochemistry , gene , medicine , endocrinology
Hepatic diseases leading to fibrosis affect millions of individuals worldwide and are a major public health challenge. Although, there have been many advances in understanding hepatic fibrogenesis, an effective therapy remains elusive. Studies focus primarily on activation of the hepatic stellate cells (HSCs), the principal fibrogenic cells in the liver; however, fewer numbers of studies have examined molecular mechanisms that deactivate HSC, controlling the profibrogenic phenotype. In the present study, we evaluated cellular and molecular actions of the chemical triclosan (TCS) in reverting activated HSCs to a quiesced phenotype. We demonstrated that the inhibition of the enzyme fatty acid synthase by TCS in activated HSCs promotes survival of the cells and triggers cellular and molecular changes that promote cellular phenotypic reversion, offering potentially new therapeutic directions.