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Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
Author(s) -
Zhao Yuhang,
Su Xin,
Gao Yanrong,
Yin Haijing,
Wang Li,
Qiao Rui,
Wang Suhua
Publication year - 2019
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22334
Subject(s) - inflammation , arsenic , autophagy , arsenite , lung , carcinogenesis , chemistry , medicine , immunology , cancer , biochemistry , apoptosis , organic chemistry
Chronic arsenic exposure through water intake is a worldwide issue, which has caused many diseases. Lungs are the first target organ of arsenic and lung inflammation, autophagy, and even the onset of tumors can be induced by arsenic exposure. Here, we tested the outcome of low‐concentration arsenic exposure in rat lungs. Tissue changes, inflammation, autophagy, and other physiological responses were observed in this study. Results showed that low‐concentration exposure of arsenite through water intake could initiate autophagy and inflammation in lungs but high concentration exposure produced a weak autophagy response and accentuated inflammation with the possibility of a chronic inflammation environment emerging followed by tumorigenesis.