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Adenomatous polyposis coli as a predictor of environmental chemical‐induced transgenerational effects related to male infertility
Author(s) -
Yuan Beilei,
Wu Wei,
Zhang Huazhong,
Gu Hao,
Guo Dan,
Jiang Juncheng,
Wang Xinru
Publication year - 2019
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22331
Subject(s) - transgenerational epigenetics , microrna , infertility , gene , biology , adenomatous polyposis coli , mechanism (biology) , gene expression , dibutyl phthalate , regulation of gene expression , genetics , cancer research , pregnancy , epigenetics , chemistry , colorectal cancer , cancer , philosophy , organic chemistry , epistemology
Exposure to toxic environmental chemicals during pregnancy is a ubiquitous threat to health with potentially transgenerational consequences. However, the underlying mechanism of how transgenerational effects occur as part of environmental chemical exposure are not well understood. We investigated the potential molecular changes associated with dibutyl phthalate exposure that induced transgenerational effects, using a rat model. Through the analysis of the Gene Expression Omnibus database, we found some similar studies of environmental exposure induced transgenerational effects. Then, we analyzed one of the studies and our results to identify the adenomatous polyposis coli (APC) gene. This gene participated the most of the pathways and was upregulated in both studies. We used the miRWALK data set to predict the microRNAs which targeted the APC gene. We confirmed the miR‐30 family were significantly downregulated in F3 testis tissues and targeted the APC gene. In conclusion, the miR‐30 family/APC interaction is a potential mechanism for the transgenerational effects induced by the environmental chemical.