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Synthesis of carbazole bearing pyridopyrimidine‐substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity
Author(s) -
RifatiNixha Arleta,
Arslan Mustafa,
Gençer Nahit,
Çıkrıkıçı Kübra,
Gökçe Başak,
Arslan Oktay
Publication year - 2019
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22306
Subject(s) - sulfonamide , carbonic anhydrase , carbazole , chemistry , carbonic anhydrase i , enzyme , carbonic anhydrase ii , stereochemistry , biochemistry , organic chemistry
The synthesis of carbazole containing pyridopyrimidine‐substituted sulfonamide derivatives ( 3a‐i ) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis confirmed the structures of the compounds synthesized. The results show that all the synthesized compounds inhibited the CA I and II activities. Among them, 3a was found to be the most active ( K i : 14 µM) for hCA I and 3f ( K i : 126 µM) for hCA II.