Synthesis of carbazole bearing pyridopyrimidine‐substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity | Zendy

RifatiNixha Arleta | Zendy; Arslan Mustafa | Zendy; Gençer Nahit | Zendy; Çıkrıkıçı Kübra | Zendy; Gökçe Başak | Zendy; Arslan Oktay | Zendy

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Synthesis of carbazole bearing pyridopyrimidine‐substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity

Author(s) -

RifatiNixha Arleta,

Arslan Mustafa,

Gençer Nahit,

Çıkrıkıçı Kübra,

Gökçe Başak,

Arslan Oktay

Publication year - 2019

Publication title -

journal of biochemical and molecular toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.526

H-Index - 58

eISSN - 1099-0461

pISSN - 1095-6670

DOI - 10.1002/jbt.22306

Subject(s) - sulfonamide , carbonic anhydrase , carbazole , chemistry , carbonic anhydrase i , enzyme , carbonic anhydrase ii , stereochemistry , biochemistry , organic chemistry

The synthesis of carbazole containing pyridopyrimidine‐substituted sulfonamide derivatives ( 3a‐i ) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis confirmed the structures of the compounds synthesized. The results show that all the synthesized compounds inhibited the CA I and II activities. Among them, 3a was found to be the most active ( K i : 14 µM) for hCA I and 3f ( K i : 126 µM) for hCA II.

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