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CeO 2 nanoparticles synthesized through green chemistry are biocompatible: In vitro and in vivo assessment
Author(s) -
Naz Sania,
Kazmi Syeda Tayyaba Batool,
Zia Muhammad
Publication year - 2019
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22291
Subject(s) - chemistry , in vivo , lipid peroxidation , antioxidant , biocompatible material , nuclear chemistry , nanoparticle , toxicity , in vitro , biophysics , nanotechnology , biochemistry , materials science , organic chemistry , microbiology and biotechnology , biomedical engineering , biology , medicine
Widespread use of cerium oxide (CeO 2 ) nanoparticles (NPs) is found in almost all areas of research due to their distinctive properties. CeO 2 NPs synthesized via green chemistry have been characterized for antioxidant, phytochemical, and biological potential. Physical characterization through scanning electron microscopy, XRD, and TGA showed that the NPs are circular in shape, 20‐25 nm in size, and stable in a wide range of temperature. NPs display significant antioxidant (32.7% free radical scavenging activity) and antileishmanial (IC 50 48 µg mL −1 ) properties. In vitro toxicity tested against lymphocytes verified that NPs are biocompatible (99.38% viability of lymphocytes at 2.5 μg mL −1 ). In vivo toxicity experiments showed no harmful effects on rat serum chemistry and histology of various organs and did not even change the concentration of antioxidative enzymes, total protein contents, lipid peroxidation, and nitrosative stress. These observations are in line with the statement that plant‐based synthesis of CeO 2 NPs lessens or nullifies in vitro and in vivo toxicity and hence CeO 2 NPs are regarded as a safe and biocompatible material to be used in drug delivery.