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Trimethylamine N‐oxide as a risk marker for ischemic stroke in patients with atrial fibrillation
Author(s) -
Liang Zhaoguang,
Dong Zengxiang,
Guo Meihua,
Shen Zhaoqian,
Yin Dechun,
Hu Shuang,
Hai Xin
Publication year - 2019
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22246
Subject(s) - trimethylamine n oxide , atrial fibrillation , medicine , logistic regression , receiver operating characteristic , stroke (engine) , cardiology , confidence interval , univariate analysis , trimethylamine , area under the curve , ischemic stroke , multivariate analysis , gastroenterology , risk factor , chemistry , ischemia , biochemistry , mechanical engineering , engineering
Trimethylamine N‐oxide (TMAO) is an independent risk factor of cardiovascular disease. Our objective was to explore the relation between TMAO and ischemic stroke (IS) in patients with atrial fibrillation (AF). A total of 68 patients with AF with IS and 111 ones without IS were enrolled. The plasma levels of TMAO remarkably increased in IS‐AF patients (8.25 ± 1.58 µM) compared with patients with AF (2.22 ± 0.09 µM, P < 0.01). The receiver operating characteristic analysis revealed that the best cutoff value of TMAO to predict IS in patients with AF was 3.53 µM with 75.0% sensitivity and 92.8% specificity (area under the curve: 0.917, 95% confidence intervals: 0.877‐0.957). Univariate and multivariate logistic regression analysis showed that TMAO was an independent predictor in IS. The level of TMAO was correlated with the CHA2DS2‐VASc score. In conclusion, TMAO was an independent predictor of IS, which could potentially refine stroke stratification in patients with AF.