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Evaluation of the renoprotective effect of nano turmeric against toxic dose of copper sulfate: Role of vascular cell adhesion molecule‐1, kidney injury molecule‐1, and signal transducer and activator of transcription 3 protein expressions
Author(s) -
Alharbi Bshayer,
Fadda Laila,
Ali Hanaa M
Publication year - 2019
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22243
Subject(s) - chemistry , pharmacology , creatinine , superoxide dismutase , malondialdehyde , reactive oxygen species , kidney , cell adhesion molecule , nitric oxide synthase , nitric oxide , biochemistry , oxidative stress , medicine , immunology , organic chemistry
The aim of this study was to compare the potential renoprotective effects of turmeric (TM) and nano turmeric (NTM) with those of desferrioxamine (DSM) against copper sulfate (CS)‐induced toxicity. Rats were administered a toxic dose of CS with TM, NTM, and DSM for 1 week. Next, serum‐urea creatinine, uric acid, interleukin (IL)‐10, c‐reactive protein (CRP), and caspase‐3 levels; renal nitric oxide (NO), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), vascular cell adhesion molecule‐1 (VCAM‐1), kidney injury molecule (KIM)‐1, signal transducer and activator of transcription 3 (STAT‐3) protein expression; and nuclear factor (NF)‐κB and B‐cell lymphoma ‐2 (Bcl‐2) messenger RNA expression levels were estimated. Administration of the investigated antioxidants downregulated the marked increase in urea, creatinine, uric acid, CRP, caspase‐3, NO, MDA, VCAM‐1, kidney injury molecule (KIM‐1), STAT‐3, NF‐κB, and DNA fragmentation, and increased Bcl‐2, IL‐10, GSH, and SOD levels induced by CS. The histopathological examination confirmed the effects of the antioxidants on the investigated biochemical parameters. Interestingly, NTM exhibited a superior renoprotective effect, which was comparable with that of DSM. In conclusion, NTM was shown to be a promising candidate against CS‐induced toxicity, and several molecular mechanisms were implicated in the CS‐induced renotoxicity as well as the treatment effects of NTM.