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Telomere length analysis in residents of a community exposed to arsenic
Author(s) -
Jimenez Villarreal Joel,
Murillo Ortiz Blanca,
Martinez Garza Sandra,
Rivas Armendáriz Diana Isabel,
Boone Villa Víctor Daniel,
Carranza Rosales Pilar,
Betancourt Martínez Nadia Denys,
Delgado Aguirre Héctor,
Morán Martínez Javier
Publication year - 2019
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22230
Subject(s) - telomere , telomerase , senescence , carcinogenesis , biology , oxidative stress , carcinogen , arsenic , dna damage , genetics , microbiology and biotechnology , dna , cancer research , cancer , gene , chemistry , biochemistry , organic chemistry
Differentiated cells telomere length is an indicator of senescence or lifespan; however, in peripheral blood leukocytes the relative shortening of the telomere has been considered as a biological marker of aging, and lengthening telomere as an associated risk to cancer. Individual’s age, type of tissue, lifestyle, and environmental factors make telomere length variable. The presence of environmental carcinogens such as arsenic (As) influence as causal agents of these alterations, the main modes of action for As described are oxidative stress, reduction in DNA repair capacity, overexpression of genes, alteration of telomerase activity, and damage to telomeres. The telomeres of leukocytes resulting a finite capacity of replication due to the low or no activity of the telomerase enzyme, therefore, elongation telomere in this kind of cells is a potential biological marker associated with the development of chronic diseases and carcinogenesis.