Premium
Toxicity of iron oxide nanoparticles: Size and coating effects
Author(s) -
Abakumov Maxim A.,
Semkina Alevtina S.,
Skorikov Alexander S.,
Vishnevskiy Daniil A.,
Ivanova Anna V.,
Mironova Elena,
Davydova Galina A.,
Majouga Alexander G.,
Chekhonin Vladimir P.
Publication year - 2018
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22225
Subject(s) - polyethylene glycol , biocompatibility , nanoparticle , cytotoxicity , iron oxide nanoparticles , chemistry , nanomaterials , bovine serum albumin , coating , iron oxide , toxicity , nanotechnology , nuclear chemistry , materials science , in vitro , organic chemistry , biochemistry
Toxicological research of novel nanomaterials is a major developmental step of their clinical approval. Since iron oxide magnetic nanoparticles have a great potential in cancer treatment and diagnostics, the investigation of their toxic properties is very topical. In this paper we synthesized bovine serum albumin‐coated iron oxide nanoparticles with different sizes and their polyethylene glycol derivative. To prove high biocompatibility of obtained nanoparticles the number of in vitro toxicological tests on human fibroblasts and U251 glioblastoma cells was performed. It was shown that albumin nanoparticles’ coating provides a stable and biocompatible shell and prevents cytotoxicity of magnetite core. On long exposure times (48 hours), cytotoxicity of iron oxide nanoparticles takes place due to free radical production, but this toxic effect may be neutralized by using polyethylene glycol modification.