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Improvement in colistin‐induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin
Author(s) -
Aksu Emrah Hicazi,
Kandemir Fatih Mehmet,
Küçükler Sefa,
Mahamadu Amdia
Publication year - 2018
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22201
Subject(s) - chrysin , colistin , oxidative stress , reproductive toxicity , toxicity , sperm , pharmacology , medicine , apoptosis , chemistry , andrology , antioxidant , antibiotics , biochemistry , flavonoid
This study aimed to investigate the effect of chrysin on colistin‐induced reproductive toxicity. Twenty‐eight adult male Sprague‐Dawley rats were divided into four groups of seven rats each. Group I received physiological saline for 7 days. Group II received 50 mg/kg/day chrysin for 7 days. Group III received a total dose of 73 mg/kg colistin for 7 days. Group IV received 50 mg/kg/day chrysin by an oral gavage after the colistin treatment. Colistin causes an increase in oxidative stress (OS) in the testis. Chrysin treatment significantly decreased the OS in the chrysin + colistin group compared with the colistin group. The highest caspase‐3 and LC3B expression levels were found in the colistin group and these levels were statistically lower in the chrysin + colistin group. Colistin treatment caused a decrease in sperm motility and an increase in sperm abnormality. Chrysin treatment mitigated these side effects significantly. In conclusion, chrysin treatment can be beneficial against colistin‐induced reproductive toxicity.