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The synthesis of N ‐benzoylindoles as inhibitors of rat erythrocyte glucose‐6‐phosphate dehydrogenase and 6‐phosphogluconate dehydrogenase
Author(s) -
Bayindir Sinan,
Temel Yusuf,
Ayna Adnan,
Ciftci Mehmet
Publication year - 2018
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22193
Subject(s) - dehydrogenase , nicotinamide adenine dinucleotide phosphate , glucose 6 phosphate dehydrogenase , biochemistry , nicotinamide adenine dinucleotide , chemistry , enzyme , lactate dehydrogenase , pentose phosphate pathway , nad+ kinase , glycolysis , oxidase test
Glucose‐6‐phosphate dehydrogenase (G6PD) and 6‐phosphogluconate dehydrogenase (6PGD) play an important function in various biochemical processes as they generate reducing power of the cell. Thus, metabolic reprogramming of reduced nicotinamide adenine dinucleotide phosphate (NADPH) homeostasis is reported to be a vital step in cancer progression as well as in combinational therapeutic approaches. In this study, N‐ benzoylindoles 9a‐ ‐ 9d , which form the main framework of many natural indole derivatives such as indomethacin and N ‐benzoylindoylbarbituric acid, were synthesized through three easy and effective steps as an in vitro inhibitor effect of G6PD and 6PGD. The N ‐benzoylindoles inhibited the enzymatic activity with IC 50 in the range of 3.391505 μM for G6PD and 2.19–990 μM for 6PGD.