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Modulatory effects of some natural products on hepatotoxicity induced by combination of sodium valproate and paracetamol in rats
Author(s) -
Zaky Hanan S.,
Gad Amany M.,
Nemr Ekram,
Hassan Wedad,
Abd ElRaouf Ola M.,
Ali Aza A.
Publication year - 2018
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22162
Subject(s) - chemistry , malondialdehyde , pharmacology , nigella sativa , acetaminophen , glutathione , alkaline phosphatase , glutathione peroxidase , bilirubin , cyp2e1 , curcuma , albumin , superoxide dismutase , biochemistry , medicine , antioxidant , traditional medicine , cytochrome p450 , enzyme
Possible hepatoprotective effect of Curcuma longa and/or Nigella sativa against hepatotoxicity induced by coadministration of sodium valproate (SV) and paracetamol was studied. Rats were divided into 10 groups, control groups 1, 2, 3, and 4 received vehicles, C. longa (200 mg/kg, p.o.), N. sativa (250 mg/kg, p.o.), or both herbs for 21 days, respectively. Toxicity groups 5, 6, and 7 received SV (300 mg/kg, i.p.), paracetamol (1000 mg/kg, p.o.) for the last 4 days or both for 21 days, respectively. Protection groups 8, 9, and 10 received C. longa , N. sativa , or both, respectively, 1 h before the administration of both the drugs for 21 days. SV and/or paracetamol significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, relative liver/body weight ratio, malondialdehyde (MDA), tumor necrosis factor alpha (TNF‐α), and caspase‐3 (Casp‐3) while significantly decreased albumin, total protein, glutathione (GSH) reduced, GSH peroxidase, and superoxide dismutase (SOD). Preadministration of C. longa and/or N. sativa caused protective effect against the hepatotoxicity induced by both drugs.