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Reproductive toxic impact of subchronic treatment with combined butylparaben and triclosan in weanling male rats
Author(s) -
Riad Madeha A.,
AbdRabo Marwa M.,
Abd El Aziz Samy A.,
El Behairy Adel M.,
Badawy Mohamed M.
Publication year - 2018
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.22037
Subject(s) - triclosan , chemistry , malondialdehyde , catalase , pharmacology , luteinizing hormone , medicine , superoxide dismutase , testosterone (patch) , endocrinology , endocrine disruptor , hormone , endocrine system , oxidative stress , pathology
The effect of treatment with combined butylparaben and triclosan on male gonadal toxicity in weanling rats was investigated. All treated groups experienced atrophy in the ventral prostate and seminal vesicle, likewise significant depletion in the number and motility of sperm. Given individually or combined butylparaben and triclosan, significantly decreased testosterone, luteinizing hormone, and follicle‐stimulating hormone levels. Individual treatment with tested compounds caused significant elevation in the E 2 level, whereas combined treatment did not alter the E 2 level. Testicular DNA damage was recorded in all treated groups. Moreover, the testicular malondialdehyde level was significantly elevated, along with a significant decrease in catalase enzyme activity in all treated groups. Superoxide dismutase enzyme activity was significantly decreased in the butylparaben‐treated group, increased in the triclosan‐treated group, and nonsignificantly changed the butylparaben‐triclosan‐treated group. The combined treatment produced an endocrine disturbance with a concomitant induction of testicular oxidative stress, which may represent a common mechanism of endocrine disruptor‐mediated dysfunction.