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Evaluation of the possible nephroprotective effects of vitamin E and rosuvastatin in amikacin‐induced renal injury in rats
Author(s) -
Selim Ahmed,
khalaf Marwa M.,
Gad Amany M.,
Abd ElRaouf Ola M.
Publication year - 2017
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21957
Subject(s) - nephrotoxicity , malondialdehyde , creatinine , chemistry , endocrinology , medicine , blood urea nitrogen , vitamin e , pharmacology , glutathione , lipid peroxidation , kidney , oxidative stress , antioxidant , biochemistry , enzyme
Amikacin (AMIK) is an aminoglycoside antibiotic that possesses considerable nephrotoxic adverse effects. This study examined the protective effects of vitamin E (VIT. E) or rosuvastatin (ROSU) against AMIK‐induced nephrotoxicity. For this purpose, eight groups of rats were used. Two control groups received saline and vehicle, AMIK group (1.2 g/kg, i.p.), VIT. E group (1000 mg/kg; p.o.), ROSU group (10 mg/kg; p.o.), AMIK + VIT. E group, AMIK + ROSU group, and combination group. The results showed that AMIK significantly increased serum levels of urea and creatinine. Meanwhile, serum levels of total protein and albumin were decreased. The kidney content of malondialdehyde was increased, whereas glutathione content and catalase activity were decreased. Tumor necrosis factor‐α and nuclear transcriptional factor levels were increased. Conversely, administration of VIT. E and/or ROSU with AMIK ameliorated such damage and reduced DNA fragmentation, apoptosis, and necrosis. In conclusion, co‐administration of VIT. E, ROSU, or their combination alleviated AMIK‐induced nephrotoxicity.