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Investigation of the effect of naringenin on oxidative stress‐related alterations in testis of hydrogen peroxide‐administered rats
Author(s) -
Sahin Zafer,
Ozkaya Ahmet,
Cuce Gokhan,
Uckun Mirac,
Yologlu Ertan
Publication year - 2017
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21928
Subject(s) - naringenin , chemistry , oxidative stress , malondialdehyde , glutathione , hydrogen peroxide , endocrinology , antioxidant , medicine , lipid peroxidation , flavonoid , glutathione reductase , glutathione peroxidase , pharmacology , biochemistry , superoxide dismutase , enzyme , biology
Testis tissue is prone to oxidation because its plasma membrane contains many polyunsaturated fatty acids. Naringenin is a plant‐derived natural flavonoid. We investigated the possible ameliorative role of naringenin on the hydrogen peroxide (H 2 O 2 )‐induced testicular damage in Wistar rats. Animals received 12 mg/kg H 2 O 2 by intraperitoneal injection, and 50 mg/kg naringenin via orogastric gavage for 4 weeks. In the H 2 O 2 group, the testis malondialdehyde level increased, while the amount of reduced glutathione, glutathione transferase activities, and the testis weight decreased. There were severe testicular damages in the H 2 O 2 group otherwise their grade were less in the naringenin + H 2 O 2 group. However, the serum testosterone concentrations decreased in both the H 2 O 2 and the naringenin + H 2 O 2 groups. The testicular zinc and calcium levels reduced in the H 2 O 2 ‐treated rats. In conclusion, the administration of H 2 O 2 caused oxidative stress in the testes and naringenin supplementation decreased the H 2 O 2 ‐induced effects, except for changes in testosterone levels.