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Oxidative damage of the male reproductive system induced by paraquat
Author(s) -
Chen Qing,
Zhang Xin,
Zhao JinYan,
Lu XiaoNing,
Zheng PengSheng,
Xue Xiang
Publication year - 2017
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21870
Subject(s) - paraquat , lipid peroxidation , apoptosis , reproductive system , oxidative damage , andrology , motility , sperm , male reproductive system , oxidative phosphorylation , sperm motility , oxidative stress , biology , reproductive toxicity , semen , medicine , chemistry , endocrinology , toxicity , biochemistry , microbiology and biotechnology
The effects of paraquat (PQ) on the male reproductive system are unclear. In this study, male rats were divided into four groups (0, 0.5, 2, and 8 mg/kg) and treated with PQ by oral gavage for 8 weeks. At the end of the experiment, a significant decline in sperm count, motility, and viability and an increase in teratospermia were observed in the PQ‐treated group ( P < 0.05). Further investigation found that PQ resulted in enhanced lipid peroxidation and more apoptosis in the testis tissues, and apoptosis was likely to be associated with activation of the mitochondrial pathway. In summary, our study demonstrated oxidative damage due to PQ on the male reproductive system.