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Elevated cholesterol levels have a poor prognosis in a cholestasis scenario
Author(s) -
NuñoLámbarri Natalia,
BarberoBecerra Varenka J,
Uribe Misael,
ChávezTapia Norberto C
Publication year - 2017
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21831
Subject(s) - cholestasis , primary biliary cirrhosis , proinflammatory cytokine , oxidative stress , cholesterol , medicine , bile acid , homeostasis , chemistry , endocrinology , inflammation
Cholestasis results from defective bile flow through the biliary ducts leading to the accumulation of bile acids (BAs) in hepatocytes and serum. It has been seen that cholestasis is associated with hypercholesterolemia, which is a prerequisite for gallstone formation and primary biliary cirrhosis, being some of the most common gastrointestinal disorders in Western societies. Cytotoxic BAs induce proinflammatory mediators, oxidative stress, and apoptosis in hepatocytes, whereas cytoprotective BAs prevent them; they can also modify the plasmatic membrane structure of cells or mitochondrial outer membrane properties as well as the distribution of cholesterol, altering various proteins involved in BAs homeostasis.