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Synthesis and structure of a new trinuclear nickel(II) complex bridged by N ‐[3‐(Dimethylamino)propyl]‐ N ′‐(2‐hydroxyphenyl)oxamido: in vitro anticancer activities, and reactivities toward DNA and protein
Author(s) -
Wang JuJu,
Wang LingYang,
Zheng Kang,
Li YanTuan,
Yan CuiWei,
Wu ZhiYong
Publication year - 2017
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21829
Subject(s) - nickel , chemistry , in vitro , dna , stereochemistry , crystallography , biochemistry , organic chemistry
Abstract A new trinickel(II) complex bridged by N ‐[3‐(dimethylamino)propyl]‐ N ′‐(2‐hydroxylphenyl)oxamido (H 3 pdmapo), namely [Ni 3 (pdmapo) 2 (H 2 O) 2 ]⋅4CH 3 OH, was synthesized and characterized by X‐ray single‐crystal diffraction and other methods. In the molecule, two symmetric cis‐ pdmapo 3− mononickel(II) complexes as a “complex ligand” using the carbonyl oxygen atoms coordinate to the center nickel(II) ion situated on an inversion point. The Ni···Ni distance through the oxamido bridge is 5.2624(4) Å. The center nickel(II) ion and the lateral ones have octahedral and square‐planar coordination geometries, respectively. In the crystal, a three‐dimensional supramolecular network dominated by hydrogen bonds is observed. The reactivity toward DNA/protein bovine serum albumin (BSA) revealed that the complex could interact with herring sperm DNA ( HS ‐DNA) through the intercalation mode and quench the intrinsic fluorescence of BSA via a static mechanism. The in vitro anticancer activities suggested that the complex is active against the selected tumor cell lines.