Premium
Neuro‐Modulation of Immuno‐Endocrine Response Induced by Kaliotoxin of Androctonus Scorpion Venom
Author(s) -
LadjelMendil Amina,
MartinEauclaire MarieFrance,
LarabaDjebari Fatima
Publication year - 2016
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21824
Subject(s) - endocrine system , endocrinology , medicine , scorpion , hormone , hypothalamus , thyroid , venom , stimulation , central nervous system , oxidative stress , thyroid function , chemistry , biology , biochemistry
Kaliotoxin (KTX), a specific blocker of potassium channels, exerts various toxic effects due to its action on the central nervous system. Its use in experimental model could help the understanding of the cellular and molecular mechanisms involved in the neuropathological processes related to potassium channel dysfunctions. In this study, the ability of KTX to stimulate neuro‐immuno‐endocrine axis was investigated. As results, the intracerebroventricular injection of KTX leads to severe structural–functional alterations of both hypothalamus and thyroid. These alterations were characterized by a massive release of hormones’ markers of thyroid function associated with damaged tissue which was infiltrated by inflammatory cell and an imbalanced redox status. Taken together, these data highlight that KTX is able to modulate the neuro‐endocrine response after binding to its targets leading to the hypothalamus and the thyroid stimulation, probably by inflammatory response activation and the installation of oxidative stress in these organs.