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Acute Administration of Diazepam Provokes Redox Homeostasis Imbalance in the Rat Brain: Prevention by Simvastatin
Author(s) -
Eger Guilherme André,
Ferreira Vinícius Vialle,
Batista Camila Ribeiro,
Bonde Henrique LuisPetrek,
Lima Daniela Delwing,
Rodrigues André Felipe,
da Cruz José Geraldo Pereira,
Magro Débora Delwing Dal
Publication year - 2016
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21815
Subject(s) - tbars , simvastatin , oxidative stress , thiobarbituric acid , chemistry , superoxide dismutase , pharmacology , antioxidant , glutathione peroxidase , diazepam , catalase , endocrinology , glutathione , medicine , lipid peroxidation , biochemistry , enzyme
We investigated the effects of acute diazepam (DZP) administration on thiobarbituric acid‐reactive substance (TBARS) levels, protein carbonyl content, and on the activities of the antioxidant enzymes catalase, glutathione peroxidase, and superoxide dismutase in the brain of rats. Additionally, we investigated the antioxidant role of chronic pretreatment with simvastatin on the effects provoked by DZP. Simvastatin was administered (1 or 10 mg/kg by oral gavage) for 30 days. On the 30th day of treatment, groups were randomized and DZP was administered (0.5 or 1.0 mg/kg by intraperitoneal injection). Control groups received saline. Results showed that DZP enhanced TBARS levels and protein carbonyl content and altered enzymatic activity in the brain of rats. Simvastatin prevented most of the alterations caused by DZP on the oxidative stress parameters. Data indicate that DZP administration causes an oxidative imbalance in the brain areas studied; however, in the presence of simvastatin, some of these alterations in oxidative stress were prevented.