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E‐Cadherin, CD44v6, and Insulin‐Like Growth Factor‐II mRNA‐Binding Protein 3 Expressions in Different Stages of Hydatidiform Moles
Author(s) -
Wang Jiajun,
Zhao Min,
Xiao Jianping,
Wu Man,
Song Yaohua,
Yin Yongxiang
Publication year - 2016
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21809
Subject(s) - cadherin , insulin like growth factor , andrology , biomarker , messenger rna , chemistry , growth factor , medicine , endocrinology , biology , receptor , gene , biochemistry , cell
E‐cadherin, CD44v6, and IMP3 expression in partial, complete, and invasive hydatidiform moles (HMs) was evaluated. High E‐cadherin expression with low CD44v6 expression was observed in partial, complete, and invasive HMs, as well as in normal placental tissues; and there was no significant difference in E‐cadherin and CD44v6 expression among the four groups. However, IMP3 expression was gradually decreased in the order of normal placental tissues, partial HMs, complete HMs, and invasive HMs; wherein, invasive HMs had the lowest level. Low IMP3 expression may serve as a prognostic biomarker for HMs, and IMP3 may play a certain role in HMs progression.