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Fucoxanthin Inhibits the Inflammation Response in Paw Edema Model through Suppressing MAPKs, Akt, and NFκB
Author(s) -
Choi JunHui,
Kim NaHyun,
Kim SungJun,
Lee HyoJeong,
Kim Seung
Publication year - 2016
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21769
Subject(s) - fucoxanthin , protein kinase b , superoxide dismutase , nitric oxide , chemistry , protein kinase a , kinase , carrageenan , nitric oxide synthase , pharmacology , inflammation , biochemistry , phosphorylation , biology , oxidative stress , immunology , organic chemistry , carotenoid
Undaria pinnatifida is a well‐known traditional Korean food with a variety of biological activities. Carrageenan (carr) is commonly used to induce paw edema in animal models. This study was designed to elucidate the processes underlying the anti‐inflammatory effect of fucoxanthin isolated from the sporophyll of U. pinnatifida in carr‐induced paw edema in ICR mice. Fucoxanthin significantly decreased carr‐induced increased nitric oxide levels in the plasma of mice with carr‐induced paw edema. Fucoxanthin protected catalase (CAT) and superoxide dismutase (SOD) activity against disruption in mice with carr‐induced paw edema. In addition, fucoxanthin repressed carr‐induced activation of inducible nitric oxide synthase, cyclooxygenase‐2, and nuclear factor kappa B, as well as carr‐induced phosphorylation of mitogen‐activated protein kinase, extracellular signal‐regulated kinase, c‐Jun N‐terminal kinase, p38, and protein kinase B/Akt. These results suggest that fucoxanthin may have therapeutic potential as a treatment for patients with inflammatory diseases.