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Crocin Prevents Patulin‐Induced Acute Toxicity in Cardiac Tissues via the Regulation of Oxidative Damage and Apoptosis
Author(s) -
Boussabbeh Manel,
Ben Salem Intidhar,
Neffati Fadwa,
Najjar Mohamed Fadhel,
Bacha Hassen,
AbidEssefi Salwa
Publication year - 2015
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21718
Subject(s) - patulin , cardiotoxicity , crocin , superoxide dismutase , catalase , pharmacology , oxidative stress , antioxidant , reactive oxygen species , chemistry , mycotoxin , toxicity , biochemistry , medicine , food science , organic chemistry
Patulin (PAT) is a mycotoxin produced by several species of the genera of Penicillium, Aspergillus , and Byssochlamys principally by Penicillium expansum . This mycotoxin is suspected to affect several organs including kidney and liver. However, its toxic effect on heart remains unknown. The present study investigated for the first time the cardiotoxic effect of PAT in mice. We demonstrated that PAT increased creatinin phosphokinase (CPK) level, induced lipoperoxydation and protein oxidation, and triggered the antioxidant enzymes such as superoxide dismutase and catalase activities. We also demonstrated that acute administration of PAT triggers apoptosis via P53 overexpression and caspase 3 activation. We further investigated the antioxidant efficiency of crocin (CRO), a carotenoid pigment, against PAT‐induced cardiotoxicity. We found that pretreatment with CRO prevents cardiac impairment by reducing CPK levels, restoring the redox statute and suppressing apoptosis. Collectively, our data provide new preventive effect of CRO toward PAT‐induced cardiotoxicity in mice.