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Synthesis and Structure of a New Copper(II) Coordination Polymer Alternately Bridged by Oxamido and Carboxylate Groups: Evaluation of DNA/BSA Binding and Cytotoxic Activities
Author(s) -
Jin XiaoTing,
Zheng Kang,
Li YanTuan,
Wu ZhiYong,
Yan CuiWei
Publication year - 2015
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21703
Subject(s) - chemistry , hydrogen bond , crystallography , copper , carboxylate , coordination polymer , intercalation (chemistry) , supramolecular chemistry , stacking , bovine serum albumin , crystal structure , oxamide , stereochemistry , inorganic chemistry , molecule , organic chemistry , biochemistry
A new one‐dimensional (1D) copper(II) coordination polymer {[Cu 2 (dmaepox)(dabt)](NO 3 )·0.5 H 2 O} n , where H 3 dmaepox and dabt denote N ‐benzoato‐ N ′‐(3‐methylaminopropyl)oxamide and 2,2′‐diamino‐4,4′‐bithiazole, respectively, was synthesized and characterized by single‐crystal X‐ray diffraction and other methods. The crystal structure analysis revealed that the two copper(II) ions are bridged alternately by cis ‐oxamido and carboxylato groups to form a 1‐D coordination polymer with the corresponding Cu···Cu separations of 5.1946(19) and 5.038(2) Å. There is a three‐dimensional supramolecular structure constructed by hydrogen bonding and π–π stacking interactions in the crystal. The reactivity towards herring sperm DNA ( HS ‐DNA) and bovine serum albumin (BSA) indicated that the copper(II) polymer can interact with the DNA in the mode of intercalation, and bind to BSA responsible for quenching of tryptophan fluorescence by the static quenching mechanism. The in vitro cytotoxicity suggested that the copper(II) polymer exhibits cytotoxic effects against the selected tumor cell lines.