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Synthesis and Structure of a Ternary Copper(II) Complex with Mixed Ligands of Diethylenetriamine and Picrate: DNA/Protein‐Binding Property and In Vitro Anticancer Activity Studies
Author(s) -
Shi YaNing,
Zheng Kang,
Zhu Ling,
Li YanTuan,
Wu ZhiYong,
Yan CuiWei
Publication year - 2015
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21688
Subject(s) - chemistry , picrate , crystallography , molar conductivity , square pyramidal molecular geometry , hydrogen bond , copper , supramolecular chemistry , quenching (fluorescence) , monoclinic crystal system , bovine serum albumin , stereochemistry , crystal structure , metal , fluorescence , molecule , organic chemistry , ion , biochemistry , physics , quantum mechanics
Based on the importance of the design and synthesis of transition metal complexes with noncovalent DNA/protein‐binding abilities in the field of metallo pharmaceuticals, a new mononuclear ternary copper(II) complex with mixed ligands of diethylenetriamine (dien) and picrate anion (pic), identified as [Cu(dien)(pic)](pic), was synthesized and characterized by elemental analysis, molar conductivity measurement, infrared spectrum, electronic spectral studies, and single‐crystal X‐ray diffractometry. The structure analysis reveals that the copper(II) complex crystallizes in the monoclinic space group P 2 1 /c, and the copper(II) ion has a distorted square pyramidal coordination geometry. A two‐dimensional supramolecular structure is formed through hydrogen bonds. The DNA/bovine serum albumin (BSA)‐binding properties of the complex are explored, indicating that the complex can interact with herring sperm DNA via intercalation mode and bind to BSA responsible for quenching of tryptophan fluorescence by static quenching mechanism. The in vitro anticancer activity shows that the copper(II) complex is active against the selected tumor cell lines.