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Lophirones B and C Extenuate AFB 1 ‐Mediated Oxidative Onslaught on Cellular Proteins, Lipids, and DNA through Nrf‐2 Expression
Author(s) -
Ajiboye Taofeek O.,
Yakubu Musa T.,
Oladiji Adenike T.
Publication year - 2014
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21598
Subject(s) - oxidative phosphorylation , dna , chemistry , protein expression , oxidative stress , microbiology and biotechnology , biochemistry , biology , gene
The capability of lophirones B and C to extenuate aflatoxin B 1 (AFB 1 )‐mediated onslaught on cellular proteins, lipids, and DNA was investigated for 6 weeks. Lophirones B and C significantly ( P < 0.05) increase the expression and specific activity of cytoprotective enzymes (glutathione‐ S ‐trans‐ferase, nioctinamide adenine dicludeotide:quinone oxidoreductase‐1, epoxide hydrolase, and uridyl glucuronosyl transferase). There was significant ( P < 0.05) reduction in the level of antioxidant system in AFB 1 ‐induced hepatocarcinogenesis. Furthermore, lophirones B and C significantly ( P < 0.05) attenuated AFB 1 ‐mediated decrease in the specific activities of antioxidant enzymes. Oxidative stress biomarkers, malondialdehyde, lipid hydroperoxides, conjugated dienes, protein carbonyl, and fragmented DNA were significantly ( P < 0.05) elevated in AFB 1 ‐treated rats. Although lophirones B and C did not significantly ( P < 0.05) alter these biomarkers, an AFB 1 ‐mediated increase in these biomarkers was significantly attenuated. Results obtained showed that lophirones B and C extenuate AFB 1 ‐mediated onslaught on cellular proteins, lipids, and DNA by enhancing nuclear erythroid–related factor‐2 expression.

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