Premium
Curcumin Attenuates Cr(VI)‐Induced Ascites and Changes in the Activity of Aconitase and F 1 F 0 ATPase and the ATP Content in Rat Liver Mitochondria
Author(s) -
GarcíaNiño Wylly Ramsés,
Zazueta Cecilia,
Tapia Edilia,
PedrazaChaverri José
Publication year - 2014
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21595
Subject(s) - aconitase , mitochondrion , ascites , curcumin , atpase , chemistry , biochemistry , medicine , endocrinology , enzyme , biology
Occupational and environmental exposure to potassium dichromate (K 2 Cr 2 O 7 ), a hexavalent chromium compound, can result in liver damage associated with oxidative stress and mitochondrial dysfunction. The purpose of this study was to evaluate the effect of the antioxidant curcumin (400 mg/kg b.w.) on the K 2 Cr 2 O 7 ‐induced injury, with special emphasis on ascitic fluid accumulation and oxidative phosphorylation mitochondrial enzymes and the adenosine triphosphate (ATP) levels in isolated mitochondria from livers of rats treated with K 2 Cr 2 O 7 (15 mg/kg b.w.). Thus, curcumin attenuated the ascites generation, prevented the decrease in the activities of aconitase and F 1 F 0 ATPase, and maintained the ATP levels. The activity of complex II was not completely reestablished by curcumin, whereas complexes III and IV activities were unchanged.