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Ellagic Acid Antiinflammatory and Antiapoptotic Potential Mediate Renoprotection in Cisplatin Nephrotoxic Rats
Author(s) -
ElGarhy Amany M.,
Abd ElRaouf Ola M.,
ElSayeh Bahia M.,
Fawzy Hala M.,
Abdallah Dalaal M.
Publication year - 2014
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21587
Subject(s) - nephrotoxicity , chemistry , nitric oxide , blood urea nitrogen , ellagic acid , creatinine , pharmacology , renal function , endocrinology , kidney , medicine , biochemistry , antioxidant , polyphenol , organic chemistry
Ellagic acid (EA) renoprotective effect against cisplatin (CIS)‐induced nephrotoxicity remains elusive. Therefore, male Sprague–Dawley rats received CIS alone or EA (10 and 30 mg/kg, p.o.) for 5 days before and after CIS injection. CIS increased serum levels of blood urea nitrogen, creatinine, γ‐glutamyl transferase, and reduced those of albumin and total protein. It also raised serum endothelin‐1, as well as serum and renal nitric oxide, tumor necrosis factor‐α, and monocyte chemoattractant protein‐1. CIS enhanced the renal caspase‐3, hemeoxygenase (HO)‐1, nuclear factor‐κB, and inducible nitric oxide. EA hampered CIS‐induced nephrotoxicity manifested by an enhancement of the glomerular filtration rate which was associated by the reduction of inflammatory mediators and the apoptotic marker in the serum and/or kidney. The present study discloses that EA suppresses HO‐1 and, its renoprotection is also linked to its anti‐inflammatory and antiapoptotic properties, as well as the reduction of nitric oxide and endothelin‐1.