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Efficient Synthesis and Antioxidant Evaluation of 2‐Aryl‐3‐(Pyrimidin‐2‐yl)‐Thiazolidinones
Author(s) -
Campos José C.,
Gouvêa Daniela P.,
Ribeiro Camila da S.,
Dutra Filipe S. P.,
Stefanello Francieli M.,
Pereira Claudio M. P.,
Cunico Wilson,
Siqueira Geonir M.
Publication year - 2013
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21506
Subject(s) - abts , chemistry , dpph , antioxidant , aryl , radical , organic chemistry , combinatorial chemistry , nuclear chemistry , alkyl
In the present study, we reported the efficient synthesis of 11 3‐(pyrimidin‐2‐yl)‐thiazolidinones in good yields using molecular sieve as the desiccant agent. In addition, we have evaluated the antioxidant capacity of the synthesized compounds by the 2,2‐diphenyl‐2‐picrylhydrazyl hydrate (DPPH•) and the 2,2‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) diammonium salt (ABTS +• ) radicals scavenging assay. Six compounds showed antioxidant activity towards DPPH• (EC 50 between 16.13 and 49.94 µg/mL) and also demonstrated excellent activity regarding ABTS +• (TEAC: 10.32–53.52). These results showed that compounds 3‐(pyrimidin‐2‐yl)‐thiazolidinones may be easily synthesized by a less expensive procedure and could be a good starting point to the development of new antioxidant compounds. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:445‐450, 2013; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21506